Locus revealed: Painlessness via loss of NaV1.7 at central terminals of sensory neurons
How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 May 2021
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| In: |
Neuron
Year: 2021, Volume: 109, Issue: 9, Pages: 1413-1416 |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2021.04.011 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2021.04.011 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896627321002610 
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| Author Notes: | Manuela Simonetti and Rohini Kuner |
| Summary: | How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia. |
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| Item Description: | Gesehen am 18.10.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2021.04.011 |