Locus revealed: Painlessness via loss of NaV1.7 at central terminals of sensory neurons
How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia.
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 May 2021
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| In: |
Neuron
Year: 2021, Jahrgang: 109, Heft: 9, Pages: 1413-1416 |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2021.04.011 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2021.04.011 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896627321002610 
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| Verfasserangaben: | Manuela Simonetti and Rohini Kuner |
| Zusammenfassung: | How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia. |
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| Beschreibung: | Gesehen am 18.10.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1097-4199 |
| DOI: | 10.1016/j.neuron.2021.04.011 |