Association of TGF-β1 and IL-10 gene polymorphisms with osteoporosis in a study of taiwanese osteoporotic patients
Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the ris...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 June 2021
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| In: |
Genes
Year: 2021, Volume: 12, Issue: 6, Pages: 1-12 |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes12060930 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/genes12060930 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4425/12/6/930 
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| Author Notes: | Min-Yu Tu, Kuei-Yang Han, Ying-Wei Lan, Ku-Yi Chang, Cheng-Wei Lai, Theresa Staniczek, Chung-Yu Lai, Kowit-Yu Chong and Chuan-Mu Chen |
| Summary: | Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. |
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| Item Description: | Gesehen am 18.10.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes12060930 |