Psychophysiological stress-reactivity in clinical and non-clinical voice-hearers
Background: Psychosis is associated with dysregulation of psychophysiological stress-reactivity, including in subjective, autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) parameters. Aims: This study investigated whether dysregulated psychophysiological stress-reactivity is sp...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 July 2021
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| In: |
Schizophrenia research
Year: 2021, Volume: 235, Pages: 52-59 |
| ISSN: | 1573-2509 |
| DOI: | 10.1016/j.schres.2021.07.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.schres.2021.07.005 Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1016%2Fj.schres.2021.07.005&DestApp=DOI&SrcAppSID=F1Wb2dPiOuA63bJJd5Y&SrcJTitle=SCHIZOPHRENIA+RESEARCH&DestDOIRegistrantName=Elsevier 
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| Author Notes: | David Baumeister, Toby Pillinger, Oliver Howes, Emmanuelle Peters |
| Summary: | Background: Psychosis is associated with dysregulation of psychophysiological stress-reactivity, including in subjective, autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) parameters. Aims: This study investigated whether dysregulated psychophysiological stress-reactivity is specifically associated with auditory verbal hallucinations (AVHs) or psychosis more generally by comparing voice-hearers with and without a need for care. Method: Clinical (n = 20) and non-clinical voice-hearers (n = 23), as well as a healthy control group with no voices (n = 23), were compared on HPA and ANS responses, and subjective reactivity, to a psychophysiological stress paradigm, the socially evaluative cold pressor test. Results: Measures of HPA function in both clinical and non-clinical voice-hearers diverged from non-voicehearing controls. Clinical participants showed a blunted peak response compared to both non-clinical groups (p = 0.02), whilst non-clinical voice-hearers showed, at trend-level, reduced cortisol levels during stress exposure compared to both clinical voice-hearers (p = 0.07) and healthy controls (p = 0.07), who unexpectedly did not differ from each other (p = 0.97). Clinical participants showed greater subjective stress levels than both nonclinical groups (p < 0.001), as well as greater anticipatory stress (p = 0.001) and less recovery. There were no differences between groups on parameters of the ANS (all p > 0.05). Conclusions: Dysregulated psychophysiological stress-function is present in clinical voice-hearers, and partially discriminates them from non-clinical voice-hearers. Overall, the present findings identified specific potential psychophysiological markers of risk and resilience in auditory verbal hallucinations and need for care. |
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| Item Description: | Gesehen am 20.10.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1573-2509 |
| DOI: | 10.1016/j.schres.2021.07.005 |