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Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14)

Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 expression on MM cells reveals as a prognostic factor in patients treated with high-dose ch...

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Main Authors: Hundemer, Michael (Author) , Klein, Ulrike (Author) , Hose, Dirk (Author) , Raab, Marc-Steffen (Author) , Cremer, Friedrich Walter (Author) , Jauch, Anna (Author) , Benner, Axel (Author) , Heiß, Christiane (Author) , Moos, Marion (Author) , Ho, Anthony Dick (Author) , Goldschmidt, Hartmut (Author)
Format: Article (Journal)
Language:English
Published: 24 September 2007
In: Bone marrow transplantation
Year: 2007, Volume: 40, Issue: 11, Pages: 1033-1037
ISSN:1476-5365
DOI:10.1038/sj.bmt.1705857
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bmt.1705857
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Author Notes:M. Hundemer, U. Klein, D. Hose, M.-S. Raab, F. W. Cremer, A. Jauch, A. Benner, C. Heiss, M. Moos, A.D. Ho and H. Goldschmidt
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Summary:Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 expression on MM cells reveals as a prognostic factor in patients treated with high-dose chemotherapy. MM cells of 99 patients prior to treatment with high-dose chemotherapy were analysed for CD56 expression by flow cytometry. Multivariable analysis of event-free survival in these patients showed no statistically significant difference between the CD56(-) (n=28) and the CD56(+) (n=71) group. The lack of CD56 expression on MM cells of these patients correlated significantly with the presence of translocation (11;14) (t(11;14)) (estimated correlation coefficient=0.655 95%, confidence interval (0.481; 0.779)). In summary, our results indicate that lack of CD56 expression on MM cells is not a prognostic marker in patients treated with high-dose chemotherapy, but is associated with t(11;14).
Item Description:Gesehen am 20.10.2021
Physical Description:Online Resource
ISSN:1476-5365
DOI:10.1038/sj.bmt.1705857

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