Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14)
Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 expression on MM cells reveals as a prognostic factor in patients treated with high-dose ch...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 September 2007
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| In: |
Bone marrow transplantation
Year: 2007, Jahrgang: 40, Heft: 11, Pages: 1033-1037 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/sj.bmt.1705857 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bmt.1705857
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| Verfasserangaben: | M. Hundemer, U. Klein, D. Hose, M.-S. Raab, F. W. Cremer, A. Jauch, A. Benner, C. Heiss, M. Moos, A.D. Ho and H. Goldschmidt |
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| 245 | 1 | 0 | |a Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14) |c M. Hundemer, U. Klein, D. Hose, M.-S. Raab, F. W. Cremer, A. Jauch, A. Benner, C. Heiss, M. Moos, A.D. Ho and H. Goldschmidt |
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| 520 | |a Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 expression on MM cells reveals as a prognostic factor in patients treated with high-dose chemotherapy. MM cells of 99 patients prior to treatment with high-dose chemotherapy were analysed for CD56 expression by flow cytometry. Multivariable analysis of event-free survival in these patients showed no statistically significant difference between the CD56(-) (n=28) and the CD56(+) (n=71) group. The lack of CD56 expression on MM cells of these patients correlated significantly with the presence of translocation (11;14) (t(11;14)) (estimated correlation coefficient=0.655 95%, confidence interval (0.481; 0.779)). In summary, our results indicate that lack of CD56 expression on MM cells is not a prognostic marker in patients treated with high-dose chemotherapy, but is associated with t(11;14). | ||
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| 650 | 4 | |a Aged | |
| 650 | 4 | |a Biomarkers | |
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| 650 | 4 | |a Chromosomes, Human, Pair 11 | |
| 650 | 4 | |a Chromosomes, Human, Pair 17 | |
| 650 | 4 | |a Disease-Free Survival | |
| 650 | 4 | |a Dose-Response Relationship, Drug | |
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| 650 | 4 | |a Translocation, Genetic | |
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