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Functional Fc gamma receptor gene polymorphisms and long-term kidney allograft survival

The functional Fc gamma receptor (FcγR) IIIA polymorphism FCGR3A-V/F158 was earlier suggested to determine the potential of donor-specific HLA antibodies to trigger microcirculation inflammation, a key lesion of antibody-mediated renal allograft rejection. Associations with long-term transplant outc...

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Main Authors: Wahrmann, Markus (Author) , Döhler, Bernd (Author) , Arnold, Marie-Luise (Author) , Scherer, Sabine (Author) , Mayer, Katharina A. (Author) , Haindl, Susanne (Author) , Haslacher, Helmuth (Author) , Böhmig, Georg A. (Author) , Süsal, Caner (Author)
Format: Article (Journal)
Language:English
Published: 23 August 2021
In: Frontiers in immunology
Year: 2021, Volume: 12, Pages: 1-8
ISSN:1664-3224
DOI:10.3389/fimmu.2021.724331
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2021.724331
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fimmu.2021.724331
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Author Notes:Markus Wahrmann, Bernd Döhler, Marie-Luise Arnold, Sabine Scherer, Katharina A. Mayer, Susanne Haindl, Helmuth Haslacher, Georg A. Böhmig and Caner Süsal
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Summary:The functional Fc gamma receptor (FcγR) IIIA polymorphism FCGR3A-V/F158 was earlier suggested to determine the potential of donor-specific HLA antibodies to trigger microcirculation inflammation, a key lesion of antibody-mediated renal allograft rejection. Associations with long-term transplant outcomes, however, have not been evaluated to date. To clarify the impact of FCGR3A-V/F158 polymorphism on kidney transplant survival, we genotyped a cohort of 1,940 recipient/donor pairs. Analyzing 10-year death-censored allograft survival, we found no significant differences in relation to FCGR3A-V/F158. There was also no independent survival effect in a multivariable Cox model. Similarly, functional polymorphisms in two other activating FcγR, FCGR2A-H/R131 (FcγRIIA) and FCGR3B-NA1/NA2 (FcγRIIIB), were not associated with outcome. There were also no significant survival differences among patient subgroups at increased risk of rejection-related injury, such as pre-sensitized recipients (> 0% panel reactivity; n = 438) or recipients treated for rejection within the first year after transplantation (n = 229). Our study results suggest that the earlier shown association of FcγR polymorphism with microcirculation inflammation may not be strong enough to exert a meaningful effect on graft survival.
Item Description:Gesehen am 21.10.2021
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2021.724331

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