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Increased frequency of G-protein β3-subunit 825T allele in dialyzed patients with type 2 diabetes

Increased frequency of G-protein β3-subunit 825T allele in dialyzed patients with type 2 diabetes. - Background - A polymorphism (C825T) in exon 10 of the gene encoding the β3 subunit of heterotrimeric G proteins (GNβ3) has recently been described, and the T allele was found to be associated with la...

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Main Authors: Blüthner, Martin (Author) , Schmidt, Susanne (Author) , Siffert, Winfried (Author) , Knigge, Heidrun (Author) , Nawroth, Peter Paul (Author) , Ritz, Eberhard (Author)
Format: Article (Journal)
Language:English
Published: 1 April 1999
In: Kidney international
Year: 1999, Volume: 55, Issue: 4, Pages: 1247-1250
ISSN:1523-1755
DOI:10.1046/j.1523-1755.1999.00399.x
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1523-1755.1999.00399.x
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0085253815460764
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Author Notes:Martin Blüthner, Susanne Schmidt, Winfried Siffert, Heidrun Knigge, Peter Nawroth, and Eberhard Ritz
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Summary:Increased frequency of G-protein β3-subunit 825T allele in dialyzed patients with type 2 diabetes. - Background - A polymorphism (C825T) in exon 10 of the gene encoding the β3 subunit of heterotrimeric G proteins (GNβ3) has recently been described, and the T allele was found to be associated with late-onset hypertension. Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients suffering from nondiabetic renal disease or type 2 diabetes with presumed diabetic nephropathy, respectively, and in older healthy controls.
Item Description:Gesehen am 28.10.2021
Physical Description:Online Resource
ISSN:1523-1755
DOI:10.1046/j.1523-1755.1999.00399.x

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