Functional MRI using Fourier decomposition of lung signal: reproducibility of ventilation- and perfusion-weighted imaging in healthy volunteers
Purpose - To assess the reproducibility of Fourier decomposition (FD) based ventilation- and perfusion-weighted lung MRI. - Methods - Sixteen healthy volunteers were examined on a 1.5 T whole-body MR-scanner with 4-6 sets of coronal slices over the chest volume with a non-contrast enhanced steady-st...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 January 2013
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| In: |
European journal of radiology
Year: 2013, Volume: 82, Issue: 6, Pages: 1015-1022 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2012.12.003 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.ejrad.2012.12.003 Verlag, Volltext: https://www.sciencedirect.com/science/article/pii/S0720048X12006055 
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| Author Notes: | Mathieu Lederlin, Grzegorz Bauman, Monika Eichinger, Julien Dinkel, Mathilde Brault, Jürgen Biederer, Michael Puderbach |
| Summary: | Purpose - To assess the reproducibility of Fourier decomposition (FD) based ventilation- and perfusion-weighted lung MRI. - Methods - Sixteen healthy volunteers were examined on a 1.5 T whole-body MR-scanner with 4-6 sets of coronal slices over the chest volume with a non-contrast enhanced steady-state free precession sequence. The identical protocol was repeated after 24h. Reconstructed perfusion- and ventilation-weighted images were obtained through non-rigid registration and FD post-processing of images. Analysis of signal in segmented regions of interest was performed for both native and post-processed data. Two blinded chest radiologists rated image quality of perfusion- and ventilation-weighted images using a 3-point scale. - Results - Reproducibility of signal between the two time points was very good with intra-class correlation coefficients of 0.98, 0.94 and 0.86 for native, perfusion- and ventilation-weighted images, respectively. Perfusion- and ventilation-weighted images were of overall good quality with proportions of diagnostic images of 87-95% and 69-75%, respectively. Lung signal decreased from posterior to anterior slices with image quality of ventilation-weighted images in anterior areas rated worse than in posterior or perfusion-weighted images. Inter- and intra-observer agreement of image quality was good for perfusion and ventilation. - Conclusions - The study demonstrates high reproducibility of ventilation- and perfusion-weighted FD lung MRI. |
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| Item Description: | Gesehen am 03.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2012.12.003 |