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Two tumors, one target: preliminary experience with 90Y-FAPI therapy in a patient with metastasized breast and colorectal cancer

We report a patient with breast cancer (BC) diagnosed in 2009 with metachronous lymph node, liver, and bone metastases. In 2017, colorectal cancer with peritoneal metastases was additionally diagnosed and treated with 8 cycles of capecitabine due to its antitumor activity against both malignancies....

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Main Authors: Rathke, Hendrik (Author) , Fuxius, Stefan (Author) , Giesel, Frederik L. (Author) , Lindner, Thomas (Author) , Debus, Jürgen (Author) , Haberkorn, Uwe (Author) , Kratochwil, Clemens (Author)
Format: Article (Journal)
Language:English
Published: October 2021
In: Clinical nuclear medicine
Year: 2021, Volume: 46, Issue: 10, Pages: 842-844
ISSN:1536-0229
DOI:10.1097/RLU.0000000000003842
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RLU.0000000000003842
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/nuclearmed/Abstract/2021/10000/Two_Tumors,_One_Target__Preliminary_Experience.13.aspx
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Author Notes:Rathke, Hendrik MD; Fuxius, Stefan MD; Giesel, Frederik L. MD, PhD; Lindner, Thomas PhD; Debus, Jürgen MD, PhD; Haberkorn, Uwe MD, PhD; Kratochwil, Clemens MD
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Summary:We report a patient with breast cancer (BC) diagnosed in 2009 with metachronous lymph node, liver, and bone metastases. In 2017, colorectal cancer with peritoneal metastases was additionally diagnosed and treated with 8 cycles of capecitabine due to its antitumor activity against both malignancies. At progression of both diseases, FAPI PET/CT demonstrated positive tumor targeting in BC-related metastases and colorectal cancer-related metastases. The patient received an experimental therapy with 90Y-FAPI46. Although there was similar tracer uptake in the PET/CT, the radioligand therapy resulted in mixed response with disappearance of peritoneal metastases but minor efficacy treating the BC-related metastases.
Item Description:Im Titel ist "90" hochgestellt
Gesehen am 04.11.2021
Physical Description:Online Resource
ISSN:1536-0229
DOI:10.1097/RLU.0000000000003842

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