The possible role of methylglyoxal metabolism in cancer
Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phos...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 September 2021
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| In: |
Journal of enzyme inhibition and medicinal chemistry
Year: 2021, Volume: 36, Issue: 1, Pages: 2010-2015 |
| ISSN: | 1475-6374 |
| DOI: | 10.1080/14756366.2021.1972994 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/14756366.2021.1972994
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| Author Notes: | Khalid O. Alfarouk, Saad S. Alqahtani, Saeed Alshahrani, Jakob Morgenstern, Claudiu T. Supuran and Stephan J. Reshkin |
| Summary: | Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer. |
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| Item Description: | Gesehen am 05.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1475-6374 |
| DOI: | 10.1080/14756366.2021.1972994 |