Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase and belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2006
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| In: |
Cytogenetic and genome research
Year: 2006, Volume: 112, Issue: 3-4, Pages: 208-212 |
| ISSN: | 1424-859X |
| DOI: | 10.1159/000089872 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000089872 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/89872 
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| Author Notes: | U. Mahlknecht, A.D. Ho, S. Letzel, S. Voelter-Mahlknecht |
| Summary: | Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase and belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human SIRT5 genomic sequence, which spans a region of 28,182 bp and which has one single genomic locus. Human SIRT5 consists of eight exons and is found in two isoforms, which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23. |
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| Item Description: | Gesehen am 05.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1424-859X |
| DOI: | 10.1159/000089872 |