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Suppression of T-cell functions by human granulocyte arginase

Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid cell-associated arginase accounts for the suppression of immune reactivity in various models of tumor growth and chronic infections. Here we show that arginase I is liberated from human granulocytes, and very high...

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Bibliographische Detailangaben
Hauptverfasser: Munder, Markus (VerfasserIn) , Rudolph, Henriette (VerfasserIn) , Luckner-Minden, Claudia (VerfasserIn) , Giese, Thomas (VerfasserIn) , Langhans, Claus-Dieter (VerfasserIn) , Fuentes, Jose M. (VerfasserIn) , Kropf, Pascale (VerfasserIn) , Mueller, Ingrid (VerfasserIn) , Kolb, Armin (VerfasserIn) , Modolell, Manuel (VerfasserIn) , Ho, Anthony Dick (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 1, 2006
In: Blood
Year: 2006, Jahrgang: 108, Heft: 5, Pages: 1627-1634
ISSN:1528-0020
DOI:10.1182/blood-2006-11-010389
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2006-11-010389
Volltext
Verfasserangaben:Markus Munder, Henriette Schneider, Claudia Luckner, Thomas Giese, Claus-Dieter Langhans, Jose M. Fuentes, Pascale Kropf, Ingrid Mueller, Armin Kolb, Manuel Modolell, and Anthony D. Ho
Beschreibung
Zusammenfassung:Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid cell-associated arginase accounts for the suppression of immune reactivity in various models of tumor growth and chronic infections. Here we show that arginase I is liberated from human granulocytes, and very high activities accumulate extracellularly during purulent inflammatory reactions. Human granulocyte arginase induces a profound suppression of T-cell proliferation and cytokine synthesis. This T-cell phenotype is due to arginase-mediated depletion of arginine in the T-cell environment, which leads to CD3ζ chain down-regulation but does not alter T-cell viability. Our study therefore demonstrates that human granulocytes possess a previously unanticipated immunosuppressive effector function. Human granulocyte arginase is a promising pharmacologic target to reverse unwanted immunosuppression.
Beschreibung:Prepublished online as Blood first edition paper, May 18, 2006
Gesehen am 09.11.2021
Beschreibung:Online Resource
ISSN:1528-0020
DOI:10.1182/blood-2006-11-010389

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