Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type
Background. The aim of the present study was to investigate neuropsychological functions in - dementia of the Alzheimer type (DAT) with respect to morphological changes that were revealed - by quantitative magnetic resonance imaging (MRI).Methods. Twenty patients with DAT (NINCDS-ADRDA criteria) a...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 January 1997
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| In: |
Psychopharmacology
Year: 1997, Volume: 27, Issue: 1, Pages: 221-229 |
| ISSN: | 1432-2072 |
| DOI: | 10.1017/S003329179600431X |
| Online Access: | Verlag, Volltext: https://doi.org/10.1017/S003329179600431X Verlag: https://www.cambridge.org/core/journals/psychological-medicine/article/quantitative-magnetic-resonance-imaging-and-neuropsychological-functions-in-dementia-of-the-alzheimer-type/E7360AEB4BE448594DDD25076A6F2CA0# 
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| Author Notes: | J. Pantel, J. Schröder, L.R. Schad, M. Friedlinger, M.V. Knopp, R. Schmitt, M. Geissler, S. Blüml, M. Essig, H. Sauer |
| Summary: | Background. The aim of the present study was to investigate neuropsychological functions in - dementia of the Alzheimer type (DAT) with respect to morphological changes that were revealed - by quantitative magnetic resonance imaging (MRI).Methods. Twenty patients with DAT (NINCDS-ADRDA criteria) and 10 healthy age and sex - matched controls were included. The neuropsychological function was evaluated on a test - battery covering the severity of dementia, verbal and visual memory, concentration and - attention, language skills and general intelligence as well as activities of daily living. 3D MRI - sequences were acquired using a 1.5 T Siemens MAGNETOM. Whole brain volume, total - intracranial volume (TIV), volume of the frontal and temporal lobes and volumes of the - amygdalahippocampus complex (AHC) were assessed using the newly developed software NMRWin.Results. Apart from TIV all morphometric parameters differed significantly between the - diagnostic groups. AHC volumes discriminated best between the groups, with only a small overlap. - AHC atrophy exceeded generalized atrophy. These findings were confirmed when the data were - reanalysed after dividing the DAT patients into a mildly and moderately affected group. The - severity of dementia was significantly correlated with the volumes of the AHC and the volumes - of the temporal lobes bilaterally, but not with the whole brain volume and the volumes of the - frontal lobes.Conclusions. These results underline the important role of the temporal substructures for - aetiology and progression of DAT. They indicate that the volume of the AHC can be - monitored by MRI and may be used to follow up the disease process. |
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| Item Description: | Gesehen am 10.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1432-2072 |
| DOI: | 10.1017/S003329179600431X |