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The initial phase of graft-versus-host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation

The mechanisms that induce and control the alloimmune inflammation of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (allo-SCT) are still incompletely understood. In the murine system, GvHD can be suppressed by CD4+CD25+ regulatory T cells (TREG), which are generally inv...

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Main Authors: Schneider, Markus (Author) , Munder, Markus (Author) , Karakhanova, Svetlana (Author) , Ho, Anthony Dick (Author) , Görner, Martin (Author)
Format: Article (Journal)
Language:English
Published: 09 November 2006
In: Clinical and laboratory haematology
Year: 2006, Volume: 28, Issue: 6, Pages: 382-390
ISSN:1365-2257
DOI:10.1111/j.1365-2257.2006.00825.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1365-2257.2006.00825.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2257.2006.00825.x
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Author Notes:M. Schneider, M. Munder, S. Karakhanova, A.D. Ho, M. Goerner
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Summary:The mechanisms that induce and control the alloimmune inflammation of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (allo-SCT) are still incompletely understood. In the murine system, GvHD can be suppressed by CD4+CD25+ regulatory T cells (TREG), which are generally involved in the suppression of inflammatory reactions. A disruption of the homeostasis between TREG and conventional T cells might therefore be associated with the inflammatory reactions of GvHD. We repetitively measured the frequency of TREG in the peripheral blood of 29 patients within the first 71-373 days after allo-SCT and correlated the results with the clinical course. We demonstrate that the initial phase of GvHD is associated with a significant reduction of TREG in the peripheral blood, while at later stages and during intensified immunosuppressive therapy, increased numbers of TREG appear. These results might indicate a pathogenic role for reduced numbers of TREG in the induction of human GvHD.
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Physical Description:Online Resource
ISSN:1365-2257
DOI:10.1111/j.1365-2257.2006.00825.x

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