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Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging

Pathological and biochemical studies indicate that β-amyloid (βA4) deposition is a hallmark in the pathogenesis of Alzheimer's disease (AD).1-4 Neuroimaging studies demonstrate that the respective cerebral changes primarily strike the temporal lobe and the amygdala-hippocampus complex and may b...

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Main Authors: Schröder, Johannes (Author) , Pantel, Johannes (Author) , Ida, N. (Author) , Essig, Marco (Author) , Hartmann, Tobias (Author) , Knopp, Michael V. (Author) , Schad, Lothar R. (Author) , Sandbrink, Rupert (Author) , Sauer, H. (Author) , Masters, C. L. (Author) , Beyreuther, Konrad (Author)
Format: Article (Journal)
Language:English
Published: 01 October 1997
In: Molecular psychiatry
Year: 1997, Volume: 2, Issue: 6, Pages: 505-507
ISSN:1476-5578
DOI:10.1038/sj.mp.4000313
Online Access:Verlag, Volltext: https://doi.org/10.1038/sj.mp.4000313
Verlag: https://www.nature.com/articles/4000313
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Author Notes:J. Schröder, J. Pantel, N. Ida, M. Essig, T. Hartmann, M.V. Knopp, L.R. Schad, R. Sandbrink, H. Sauer, C.L. Masters, K. Beyreuther
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Summary:Pathological and biochemical studies indicate that β-amyloid (βA4) deposition is a hallmark in the pathogenesis of Alzheimer's disease (AD).1-4 Neuroimaging studies demonstrate that the respective cerebral changes primarily strike the temporal lobe and the amygdala-hippocampus complex and may be reliably assessed using quantitative magnetic resonance imaging (MRI).5,6 Therefore one may expect that reduced βA4-levels are significantly correlated with measures of the temporal lobe rather than global cerebral atrophy in AD patients. To test this hypothesis in a clinical study, cerebrospinal fluid concentrations of total β A4 and its major C-terminal variations β A4 1-40 and β A4 1-42 were compared with cerebral changes as assessed by quantitative magnetic resonance imaging (MRI). Significantly (P < 0.05) reduced β A4 1-40 and β A4 1-42 levels were found in the AD patients (17 female; six male; AD/NINCDS-ADRDA-criteria)7 in comparison to the patients with major depression (seven female; two male; DSM-III-R).8 Within the AD group, βA4 and β xA4 1-42 levels were significantly correlated with the volume of the temporal lobes (r = 0.46 and r = 0.48, respectively) but none of the other volumetric measures. These findings indicate that changes in cerebral β A4 levels contribute to temporal lobe atrophy in AD and support the possibility that βA4 is central to the etiology of AD.
Item Description:Gesehen am 16.11.2021
Physical Description:Online Resource
ISSN:1476-5578
DOI:10.1038/sj.mp.4000313

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