T-cell receptor therapy targeting mutant capicua transcriptional repressor in experimental gliomas

Gliomas are intrinsic brain tumors with a high degree of constitutive and acquired resistance to standard therapeutic modalities such as radiotherapy and alkylating chemotherapy. Glioma subtypes are recognized by characteristic mutations. Some of these characteristic mutations have shown to generate...

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Main Authors:	Kilian, Michael (Author) , Friedrich, Mirco (Author) , Sanghvi, Khwab (Author) , Green, Edward (Author) , Pusch, Stefan (Author) , Kawauchi, Daisuke (Author) , Löwer, Martin (Author) , Sonner, Jana K. (Author) , Krämer, Christopher (Author) , Zaman, Julia (Author) , Jung, Stefanie (Author) , Breckwoldt, Michael O. (Author) , Willimksy, Gerald (Author) , Eichmüller, Stefan B. (Author) , Deimling, Andreas von (Author) , Wick, Wolfgang (Author) , Sahm, Felix (Author) , Platten, Michael (Author) , Bunse, Lukas (Author)
Format:	Article (Journal)
Language:	English
Published:	15 January 2022
In:	Clinical cancer research Year: 2022, Volume: 28, Issue: 2, Pages: 378-389
ISSN:	1557-3265
DOI:	10.1158/1078-0432.CCR-21-1881
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-21-1881 Verlag, lizenzpflichtig, Volltext: https://clincancerres.aacrjournals.org/content/early/2021/11/01/1078-0432.CCR-21-1881
Author Notes:	Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin Löwer, Jana K. Sonner, Christopher Krämer, Julia Zaman, Stefanie Jung, Michael O. Breckwoldt, Gerald Willimksy, Stefan B. Eichmüller, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten, and Lukas Bunse