Potential risk of food-drug interactions: citrus polymethoxyflavones and flavanones as inhibitors of the organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1
Citrus flavonoids are not only components of daily nutrition, they are also promoted as dietary supplements and are important ingredients in traditional medicines. Interactions of flavonoids with synthetic drugs represent an often neglected issue. We therefore investigated in vitro whether the polym...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 July 2020
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| In: |
European journal of drug metabolism and pharmacokinetics
Year: 2020, Volume: 45, Issue: 6, Pages: 809-815 |
| ISSN: | 2107-0180 |
| DOI: | 10.1007/s13318-020-00634-4 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s13318-020-00634-4
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| Author Notes: | Gzona Bajraktari-Sylejmani, Johanna Weiss |
| Summary: | Citrus flavonoids are not only components of daily nutrition, they are also promoted as dietary supplements and are important ingredients in traditional medicines. Interactions of flavonoids with synthetic drugs represent an often neglected issue. We therefore investigated in vitro whether the polymethoxyflavones nobiletin, sinensetin, and tangeretin and the flavonoid rutinosides didymin, hesperidin, and narirutin can inhibit human organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1, which are important transporters mediating drug-drug and food-drug interactions. |
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| Item Description: | Gesehen am 25.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2107-0180 |
| DOI: | 10.1007/s13318-020-00634-4 |