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Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to...

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Main Authors: Nuñez, Fiesky A. (Author) , Callahan, Michael F. (Author) , Trach, Simon Martin (Author) , Burnett, Luke R. (Author) , Kislukhin, Victor (Author) , Smith, Thomas L. (Author) , Van Dyke, Mark (Author)
Format: Article (Journal)
Language:English
Published: 10 Jan 2013
In: Artificial cells, nanomedicine, and biotechnology
Year: 2013, Volume: 41, Issue: 5, Pages: 293-303
ISSN:2169-141X
DOI:10.3109/21691401.2012.747533
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/21691401.2012.747533
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Author Notes:Fiesky A. Nunez, Michael F. Callahan, Simon Trach, Luke R. Burnett, Victor Kislukhin, Thomas L. Smith & Mark Van Dyke
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Summary:Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.
Item Description:Gesehen am 29.11.2021
Physical Description:Online Resource
ISSN:2169-141X
DOI:10.3109/21691401.2012.747533

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