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Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth

Mesenchymal stromal cells (MSC) in bone marrow have been shown to be radioresistant, which is related to pronounced DNA repair mechanisms. Intraoperative radiotherapy (IORT) during breast-conserving surgery for early breast cancer is an innovative technique applying low energy x‑ray to the tumor bed...

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Bibliographic Details
Main Authors: Uhlig, Stefanie (Author) , Wuhrer, Anne (Author) , Berlit, Sebastian (Author) , Tuschy, Benjamin (Author) , Sütterlin, Marc (Author) , Bieback, Karen (Author)
Format: Article (Journal)
Language:English
Published: 6 February 2020
In: Strahlentherapie und Onkologie
Year: 2020, Volume: 196, Issue: 4, Pages: 398-404
ISSN:1439-099X
DOI:10.1007/s00066-020-01586-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00066-020-01586-z
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Author Notes:Stefanie Uhlig, Anne Wuhrer, Sebastian Berlit, Benjamin Tuschy, Marc Sütterlin, Karen Bieback
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Summary:Mesenchymal stromal cells (MSC) in bone marrow have been shown to be radioresistant, which is related to pronounced DNA repair mechanisms. Intraoperative radiotherapy (IORT) during breast-conserving surgery for early breast cancer is an innovative technique applying low energy x‑ray to the tumor bed immediately after removal of the tumor. IORT is considered to reduce the risk of local tumor recurrence by directly targeting cells of the tumor bed and altering the local microenvironment. Aim of this study was to investigate whether IORT affects the outgrowth potential of breast adipose tissue-derived MSC (bASC) as part of the tumor bed.
Item Description:Gesehen am 30.11.2021
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-020-01586-z

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