Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironm...

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Main Authors:	Tirier, Stephan Marius (Author) , Mallm, Jan-Philipp (Author) , Steiger, Simon (Author) , Poos, Alexandra (Author) , Awwad, Mohamed (Author) , Giesen, Nicola (Author) , Casiraghi, Nicola (Author) , Susak, Hana (Author) , Bauer, Katharina (Author) , Baumann, Anja (Author) , John, Lukas (Author) , Seckinger, Anja (Author) , Hose, Dirk (Author) , Müller-Tidow, Carsten (Author) , Goldschmidt, Hartmut (Author) , Stegle, Oliver (Author) , Hundemer, Michael (Author) , Weinhold, Niels (Author) , Raab, Marc-Steffen (Author) , Rippe, Karsten (Author)
Format:	Article (Journal)
Language:	English
Published:	29 November 2021
In:	Nature Communications Year: 2021, Volume: 12, Pages: 1-16
ISSN:	2041-1723
DOI:	10.1038/s41467-021-26951-z
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-26951-z Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-26951-z
Author Notes:	Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab & Karsten Rippe