Buchumschlag

A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation

Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Hosseini, Vahid (VerfasserIn) , Kalantary-Charvadeh, Ashkan (VerfasserIn) , Hajikarami, Maryam (VerfasserIn) , Fayyazpour, Parisa (VerfasserIn) , Rahbarghazi, Reza (VerfasserIn) , Totonchi, Mehdi (VerfasserIn) , Darabi, Masoud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 October 2021
In: Stem cell research & therapy
Year: 2021, Jahrgang: 12, Pages: 1-14
ISSN:1757-6512
DOI:10.1186/s13287-021-02617-x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13287-021-02617-x
Volltext
Verfasserangaben:Vahid Hosseini, Ashkan Kalantary-Charvadeh, Maryam Hajikarami, Parisa Fayyazpour, Reza Rahbarghazi, Mehdi Totonchi and Masoud Darabi
Beschreibung
Zusammenfassung:Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immunostaining, and covalent labeling to evaluate whether a small molecule modulating unsaturated fatty acids can influence the early endodermal differentiation of human-induced pluripotent stem cells (iPSCs).
Beschreibung:Gesehen am 04.12.2021
Beschreibung:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-021-02617-x

Ähnliche Einträge