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A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation

Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immu...

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Main Authors: Hosseini, Vahid (Author) , Kalantary-Charvadeh, Ashkan (Author) , Hajikarami, Maryam (Author) , Fayyazpour, Parisa (Author) , Rahbarghazi, Reza (Author) , Totonchi, Mehdi (Author) , Darabi, Masoud (Author)
Format: Article (Journal)
Language:English
Published: 21 October 2021
In: Stem cell research & therapy
Year: 2021, Volume: 12, Pages: 1-14
ISSN:1757-6512
DOI:10.1186/s13287-021-02617-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13287-021-02617-x
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Author Notes:Vahid Hosseini, Ashkan Kalantary-Charvadeh, Maryam Hajikarami, Parisa Fayyazpour, Reza Rahbarghazi, Mehdi Totonchi and Masoud Darabi
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Summary:Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immunostaining, and covalent labeling to evaluate whether a small molecule modulating unsaturated fatty acids can influence the early endodermal differentiation of human-induced pluripotent stem cells (iPSCs).
Item Description:Gesehen am 04.12.2021
Physical Description:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-021-02617-x

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