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Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl2 interacted with biologically relevant thiol...

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Main Authors: Oehninger, Luciano (Author) , Stefanopoulou, Maria (Author) , Alborzinia, Hamed (Author) , Schur, Julia (Author) , Ludewig, Stephanie (Author) , Namikawa, Kazuhiko (Author) , Muñoz-Castro, Alvaro (Author) , Köster, Reinhard W. (Author) , Baumann, Knut (Author) , Wölfl, Stefan (Author) , Sheldrick, William S. (Author) , Ott, Ingo (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Dalton transactions
Year: 2013, Volume: 42, Issue: 5, Pages: 1657-1666
ISSN:1477-9234
DOI:10.1039/C2DT32319B
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C2DT32319B
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2013/dt/c2dt32319b
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Author Notes:Luciano Oehninger, Maria Stefanopoulou, Hamed Alborzinia, Julia Schur, Stephanie Ludewig, Kazuhiko Namikawa, Alvaro Muñoz-Castro, Reinhard W. Köster, Knut Baumann, Stefan Wölfl, William S. Sheldrick and Ingo Ott
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Summary:Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl2 interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B. Pronounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved. Inhibition of tumor cell growth was accompanied by a perturbation of metabolic parameters such as cellular respiration.
Item Description:First published 26 Oct 2012
Gesehen am 06.12.2021
Physical Description:Online Resource
ISSN:1477-9234
DOI:10.1039/C2DT32319B

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