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Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

Astrocytes participate in the local innate immune response of the central nervous system. In response to stress such as ischemia, activated cells release endogenous factors known as damage-associated molecular patterns (DAMPs). Self-extracellular RNA (eRNA) is such a ubiquitous alarm signal. However...

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Bibliographic Details
Main Authors: Fischer, Silvia (Author) , Nasyrov, Emil (Author) , Brosien, Monika (Author) , Preissner, Klaus T. (Author) , Marti, Hugo (Author) , Kunze, Reiner (Author)
Format: Article (Journal)
Language:English
Published: 02 November 2021
In: Journal of neuroinflammation
Year: 2021, Volume: 18, Pages: 1-13
ISSN:1742-2094
DOI:10.1186/s12974-021-02286-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12974-021-02286-w
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Author Notes:Silvia Fischer, Emil Nasyrov, Monika Brosien, Klaus T. Preissner, Hugo H. Marti and Reiner Kunze
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Summary:Astrocytes participate in the local innate immune response of the central nervous system. In response to stress such as ischemia, activated cells release endogenous factors known as damage-associated molecular patterns (DAMPs). Self-extracellular RNA (eRNA) is such a ubiquitous alarm signal. However, it is unclear whether eRNA is involved in the early acute phase of cerebral ischemia and is sufficient to sensitize astrocytes towards a DAMP or PAMP (pathogen-associated molecular pattern) reaction.
Item Description:Gesehen am 07.12.2021
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-021-02286-w

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