The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres
Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the s...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 June 2013
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| In: |
EMBO reports
Year: 2013, Volume: 14, Issue: 8, Pages: 704-710 |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2013.87 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/embor.2013.87 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1038/embor.2013.87 
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| Author Notes: | Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin Maria Greulich-Bode, Petra Boukamp & Ingrid Grummt |
| Summary: | Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the structural integrity of these repetitive loci. Knockdown of NoRC leads to relaxation of centromeric and telomeric heterochromatin, abnormalities in mitotic spindle assembly, impaired chromosome segregation and enhanced chromosomal instability. The results demonstrate that NoRC safeguards genomic stability by coordinating enzymatic activities that establish features of repressive chromatin at centromeric and telomeric regions, and this heterochromatic structure is required for sustaining genomic integrity. |
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| Item Description: | Gesehen am 08.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2013.87 |