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ZIKA virus neutralizing antibody kinetics in antenatally exposed infants

Zika virus (ZIKV) is associated with severe congenital abnormalities and laboratory diagnosis of antenatal infection is difficult. Here we evaluated ZIKV neutralizing antibody (nAb) kinetics in infants born to mothers with PCR-confirmed ZIKV infection during pregnancy.Neonates (n = 98) had serum spe...

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Main Authors: Melo Espindola, Otavio de (Author) , Jänisch, Thomas (Author) , Nielsen-Saines, Karin (Author) , Oliveira, Raquel de Vasconcellos Carvalhaes de (Author) , Pastorino, Boris (Author) , Vasconcelos, Zilton (Author) , Gabaglia, Claudia Raja (Author) , Ribeiro, Ieda Pereira (Author) , Cunha, Denise Cotrim da (Author) , Pone, Marcos Vinicius (Author) , Carvalho, Liege Maria Abreu de (Author) , Pone, Sheila Moura (Author) , Damasceno, Luana (Author) , Zin, Andrea Araujo (Author) , Bonaldo, Myrna C (Author) , Moreira, Maria Elisabeth Lopes (Author) , Cherry, James D (Author) , de Lamballerie, Xavier (Author) , Brasil, Patrícia (Author)
Format: Article (Journal)
Language:English
Published: February 2, 2021
In: The journal of infectious diseases
Year: 2021, Volume: 224, Issue: 6, Pages: 1060-1068
ISSN:1537-6613
DOI:10.1093/infdis/jiab054
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/infdis/jiab054
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Author Notes:Otavio de Melo Espindola, Thomas Jaenisch, Karin Nielsen-Saines, Raquel de Vasconcellos Carvalhaes de Oliveira, Boris Pastorino, Zilton Vasconcelos, Claudia Raja Gabaglia, Ieda Pereira Ribeiro, Denise Cotrim da Cunha, Marcos Vinicius Pone, Liege Maria Abreu de Carvalho, Sheila Moura Pone, Luana Damasceno, Andrea Araujo Zin, Myrna C. Bonaldo, Maria Elisabeth Lopes Moreira, James D. Cherry, Xavier de Lamballerie, and Patrícia Brasil
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Summary:Zika virus (ZIKV) is associated with severe congenital abnormalities and laboratory diagnosis of antenatal infection is difficult. Here we evaluated ZIKV neutralizing antibody (nAb) kinetics in infants born to mothers with PCR-confirmed ZIKV infection during pregnancy.Neonates (n = 98) had serum specimens tested repeatedly for ZIKV nAb over the first 2 years of life using virus neutralization test (VNT). ZIKV neonatal infection was confirmed by RT-PCR in blood or urine and/or presence of ZIKV IgM antibodies, and results were correlated with infant clinical features.Postnatal laboratory evidence of ZIKV vertical transmission was obtained for 60.2% of children, while 32.7% exhibited clinical abnormalities. Congenital abnormalities were found in 37.3% of children with confirmed ZIKV infection and 31.0% of children without confirmed infection (P = .734). All but 1 child displayed a physiologic decline in ZIKV nAb, reflecting maternal antibody decay, despite an early ZIKV-IgM response in one-third of infants.Infants with antenatal ZIKV exposure do not develop ZIKV nAb despite an early IgM response. Therefore, ZIKV VNT in children is not useful for diagnosis of congenital infection. In light of these findings, it remains to be determined if children infected in utero are potentially susceptible to reinfection.
Item Description:Gesehen am 08.12.2021
Physical Description:Online Resource
ISSN:1537-6613
DOI:10.1093/infdis/jiab054

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