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PET findings and neuropsychological deficits in a case of Fahr's disease

In a case of Fahr's disease with frontal lobe type dementia and hyperkinetic-hypotone syndrome, functional changes were investigated using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) as a tracer. Computed tomography showed bilateral calcifications in the putamen and glo...

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Main Authors: Hempel, Albrecht (Author) , Henze, Marcus (Author) , Berghoff, Christopher (Author) , García Caraballo, Nohazarahit María (Author) , Ody, Reinhard (Author) , Schröder, Johannes (Author)
Format: Article (Journal)
Language:English
Published: 01 December 2001
In: Psychiatry research
Year: 2001, Volume: 108, Issue: 2, Pages: 133-140
ISSN:1872-7123
DOI:10.1016/S0165-1781(01)00308-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0165-1781(01)00308-0
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165178101003080
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Author Notes:Albrecht Hempel, Marcus Henze, Christopher Berghoff, Nohazarahit Garcia, Reinhard Ody, Johannes Schröder
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Summary:In a case of Fahr's disease with frontal lobe type dementia and hyperkinetic-hypotone syndrome, functional changes were investigated using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) as a tracer. Computed tomography showed bilateral calcifications in the putamen and globus pallidus consistent with the diagnosis of Fahr's disease and a frontally pronounced brain atrophy. In contrast, reduced glucose uptake in PET was not only confined to the areas mentioned above, but extended to the temporal and parietal cortices, bilaterally. These functional changes corresponded to the neuropsychological deficits observed, i.e. disturbed selective attention and cognitive flexibility, verbal perseverations, and declarative memory deficits. It is suggested that functional changes may precede cerebral atrophy in Fahr's disease and may reflect deficits in functional circuits, which involve both the basal ganglia and the frontal, parietal, and temporal lobes.
Item Description:Gesehen am 09.12.2021
Physical Description:Online Resource
ISSN:1872-7123
DOI:10.1016/S0165-1781(01)00308-0

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