Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study
Clinical studies indicate that patients with acute schizophrenia may benefit from benzodiazepine treatment. Therefore we investigated the benzodiazepine receptor distribution and diazepam binding in 20 patients with DSM-III schizophrenia using single photon emission computed tomography (SPECT) with...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1997
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| In: |
Psychiatry research
Year: 1997, Volume: 68, Issue: 2, Pages: 125-131 |
| ISSN: | 1872-7123 |
| DOI: | 10.1016/S0925-4927(96)02843-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0925-4927(96)02843-0 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0925492796028430 
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| Author Notes: | Johannes Schröder, Bernd Bubeck, Sibylle Demisch, Heinrich Sauer |
| Summary: | Clinical studies indicate that patients with acute schizophrenia may benefit from benzodiazepine treatment. Therefore we investigated the benzodiazepine receptor distribution and diazepam binding in 20 patients with DSM-III schizophrenia using single photon emission computed tomography (SPECT) with iomazenil as the ligand. In each patient, two SPECT images were obtained: SPECT 1 was obtained 2 h after intravenous injection of 200 MBq I-123-iomazenil. Following SPECT 1, patients received 10 mg diazepam intravenously. Twenty min later, SPECT 2 was started. The highest iomazenil uptake was found in the occipital cortex followed by the frontal and temporal cortices. Baseline iomazenil uptake in the medial frontal cortex was significantly (P < 0.05) correlated with the BPRS total score (r = 0.46). Diazepam injection led to a significant activity decrease in iomazenil binding which was greatest in the frontal regions of interest. With respect to the medial frontal cortex, this effect was significantly (P < 0.05) more pronounced in patients with a remitting than a chronic course of the disorder. These findings suggest that changes of the benzodiazepine receptor system in the frontal cortex may be associated with severity and chronicity of schizophrenia. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 25. März 1999 Gesehen am 09.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7123 |
| DOI: | 10.1016/S0925-4927(96)02843-0 |