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Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro

Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of PXR for MDR in head and neck squamous cell carcinoma (HNSCC).

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Bibliographic Details
Main Authors: Rigalli, Juan Pablo (Author) , Reuter, Tasmin (Author) , Herold-Mende, Christel (Author) , Dyckhoff, Gerhard (Author) , Haefeli, Walter E. (Author) , Weiß, Johanna (Author) , Theile, Dirk (Author)
Format: Article (Journal)
Language:English
Published: 12 March 2013
In: Cancer chemotherapy and pharmacology
Year: 2013, Volume: 71, Issue: 5, Pages: 1335-1343
ISSN:1432-0843
DOI:10.1007/s00280-013-2133-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00280-013-2133-x
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Author Notes:Juan Pablo Rigalli, Tasmin Reuter, Christel Herold-Mende, Gerhard Dyckhoff, Walter Emil Haefeli, Johanna Weiss, Dirk Theile
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Summary:Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of PXR for MDR in head and neck squamous cell carcinoma (HNSCC).
Item Description:Gesehen am 13.12.2021
Physical Description:Online Resource
ISSN:1432-0843
DOI:10.1007/s00280-013-2133-x

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