Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro
Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of PXR for MDR in head and neck squamous cell carcinoma (HNSCC).
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 March 2013
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| In: |
Cancer chemotherapy and pharmacology
Year: 2013, Jahrgang: 71, Heft: 5, Pages: 1335-1343 |
| ISSN: | 1432-0843 |
| DOI: | 10.1007/s00280-013-2133-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00280-013-2133-x |
| Verfasserangaben: | Juan Pablo Rigalli, Tasmin Reuter, Christel Herold-Mende, Gerhard Dyckhoff, Walter Emil Haefeli, Johanna Weiss, Dirk Theile |
| Zusammenfassung: | Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of PXR for MDR in head and neck squamous cell carcinoma (HNSCC). |
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| Beschreibung: | Gesehen am 13.12.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1432-0843 |
| DOI: | 10.1007/s00280-013-2133-x |