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Facile, efficient and diastereoselective synthesis of α-hydrazine tetrazoles through a novel one-pot four-component reaction

A novel and efficient method for the diastereoselective synthesis of α-hydrazine tetrazoles via an isocyanide-based multicomponent reaction is reported in good yields. The α-hydrazine tetrazoles were obtained by a facile azide Ugi four-component reaction (U-4CR) using cyclic ketones, trimethylsilyl...

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Bibliographic Details
Main Authors: Ramezanpour, Sorour (Author) , Balalaie, Saeed (Author) , Rominger, Frank (Author) , Alavijeh, Nahid S. (Author) , Bijanzadeh, Hamid Reza (Author)
Format: Article (Journal)
Language:English
Published: 25 October 2013
In: Tetrahedron
Year: 2013, Volume: 69, Issue: 50, Pages: 10718-10723
ISSN:1464-5416
DOI:10.1016/j.tet.2013.10.062
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tet.2013.10.062
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0040402013016074
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Author Notes:Sorour Ramezanpour, Saeed Balalaie, Frank Rominger, Nahid S. Alavijeh, Hamid Reza Bijanzadeh
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Summary:A novel and efficient method for the diastereoselective synthesis of α-hydrazine tetrazoles via an isocyanide-based multicomponent reaction is reported in good yields. The α-hydrazine tetrazoles were obtained by a facile azide Ugi four-component reaction (U-4CR) using cyclic ketones, trimethylsilyl azide, hydrazides, and corresponding isocyanide without any catalyst and with high bond forming efficiency at room temperature.
Item Description:Gesehen am 14.12.2021
Physical Description:Online Resource
ISSN:1464-5416
DOI:10.1016/j.tet.2013.10.062

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