An efficient and diastereoselective synthesis of hydrazino amides via a novel one-pot three-component reaction
An efficient one-pot three-component synthesis of a series of α-hydrazino amides, obtained in high diastereoselectivity and yield, was realized starting from cyclic ketones, hydrazides, and isocyanides in the presence of 10 mol % p-TsOH in ethanol at room temperature. The synthetic protocol was opti...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 February 2013
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| In: |
Tetrahedron
Year: 2013, Volume: 69, Issue: 16, Pages: 3480-3485 |
| ISSN: | 1464-5416 |
| DOI: | 10.1016/j.tet.2013.02.056 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tet.2013.02.056 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0040402013002822 
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| Author Notes: | Sorour Ramezanpour, Saeed Balalaie, Frank Rominger, Hamid Reza Bijanzadeh |
| Summary: | An efficient one-pot three-component synthesis of a series of α-hydrazino amides, obtained in high diastereoselectivity and yield, was realized starting from cyclic ketones, hydrazides, and isocyanides in the presence of 10 mol % p-TsOH in ethanol at room temperature. The synthetic protocol was optimized and the observed diastereoselectivity was measured using 1H NMR spectroscopy. |
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| Item Description: | Gesehen am 14.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1464-5416 |
| DOI: | 10.1016/j.tet.2013.02.056 |