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An efficient and diastereoselective synthesis of hydrazino amides via a novel one-pot three-component reaction

An efficient one-pot three-component synthesis of a series of α-hydrazino amides, obtained in high diastereoselectivity and yield, was realized starting from cyclic ketones, hydrazides, and isocyanides in the presence of 10 mol % p-TsOH in ethanol at room temperature. The synthetic protocol was opti...

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Hauptverfasser: Ramezanpour, Sorour (VerfasserIn) , Balalaie, Saeed (VerfasserIn) , Rominger, Frank (VerfasserIn) , Bijanzadeh, Hamid Reza (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 February 2013
In: Tetrahedron
Year: 2013, Jahrgang: 69, Heft: 16, Pages: 3480-3485
ISSN:1464-5416
DOI:10.1016/j.tet.2013.02.056
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tet.2013.02.056
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0040402013002822
Volltext
Verfasserangaben:Sorour Ramezanpour, Saeed Balalaie, Frank Rominger, Hamid Reza Bijanzadeh
Beschreibung
Zusammenfassung:An efficient one-pot three-component synthesis of a series of α-hydrazino amides, obtained in high diastereoselectivity and yield, was realized starting from cyclic ketones, hydrazides, and isocyanides in the presence of 10 mol % p-TsOH in ethanol at room temperature. The synthetic protocol was optimized and the observed diastereoselectivity was measured using 1H NMR spectroscopy.
Beschreibung:Gesehen am 14.12.2021
Beschreibung:Online Resource
ISSN:1464-5416
DOI:10.1016/j.tet.2013.02.056

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