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EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we as...

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Main Authors: Plaschke, Konstanze (Author) , Hill, Holger (Author) , Engelhardt, Ria (Author) , Thomas, C. (Author) , Haken, Rebecca von (Author) , Scholz, Mirijam Friderike (Author) , Kopitz, Jürgen (Author) , Bardenheuer, Hubert J. (Author) , Weisbrod, Matthias (Author) , Weigand, Markus A. (Author)
Format: Article (Journal)
Language:English
Published: 05 November 2007
In: Anaesthesia
Year: 2007, Volume: 62, Issue: 12, Pages: 1217-1223
ISSN:1365-2044
DOI:10.1111/j.1365-2044.2007.05255.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1365-2044.2007.05255.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2044.2007.05255.x
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Author Notes:K. Plaschke, H. Hill, R. Engelhardt, C. Thomas, R. Von Haken, M. Scholz, J. Kopitz, H.J. Bardenheuer, M. Weisbrod, M.A. Weigand
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Summary:The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM® system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
Item Description:Gesehen am 14.12.2021
Physical Description:Online Resource
ISSN:1365-2044
DOI:10.1111/j.1365-2044.2007.05255.x

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