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XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase

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Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR). Removal of the non-homologous end-joining (NHEJ) factor Ku from resected seDSB ends is crucial for HR. The coordinated actions of MRE11-CtIP nuclease...

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Main Authors: Sharma, Abhishek (Author) , Erasimus, Hélène (Author) , Pinto, Lia (Author) , Caron, Marie-Christine (Author) , Gopaul, Diyavarshini (Author) , Peterlini, Thibaut (Author) , Neumann, Katrin (Author) , Nazarov, Petr V (Author) , Fritah, Sabrina (Author) , Klink, Barbara (Author) , Herold-Mende, Christel (Author) , Niclou, Simone P (Author) , Pasero, Philippe (Author) , Calsou, Patrick (Author) , Masson, Jean-Yves (Author) , Britton, Sébastien (Author) , Van Dyck, Eric (Author)
Format: Article (Journal)
Language:English
Published: 09 September 2021
In: Nucleic acids research
Year: 2021, Volume: 49, Issue: 17, Pages: 9906-9925
ISSN:1362-4962
DOI:10.1093/nar/gkab785
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkab785
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Author Notes:Abhishek Bharadwaj Sharma, Hélène Erasimus, Lia Pinto, Marie-Christine Caron, Diyavarshini Gopaul, Thibaut Peterlini, Katrin Neumann, Petr V. Nazarov, Sabrina Fritah, Barbara Klink, Christel C. Herold-Mende, Simone P. Niclou, Philippe Pasero, Patrick Calsou, Jean-Yves Masson, Sébastien Britton, Eric Van Dyck
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