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Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Neurons within the CA3 region of the hippocampus are relatively resistant to cell death after ischemia. Alastair M. Buchan and his colleagues demonstrate that the product of the TSC1 gene, hamartin, is upregulated in CA3 neurons in response to ischemia. Hamartin promotes survival by inhibiting mTORC...

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Main Authors: Papadakis, Michalis (Author) , Hadley, Gina (Author) , Xilouri, Maria (Author) , Hoyte, Lisa C. (Author) , Nagel, Simon (Author) , McMenamin, M. Mary (Author) , Tsaknakis, Grigorios (Author) , Watt, Suzanne M. (Author) , Drakesmith, Cynthia Wright (Author) , Chen, Ruoli (Author) , Wood, Matthew J. A. (Author) , Zhao, Zonghang (Author) , Kessler, Benedikt (Author) , Vekrellis, Kostas (Author) , Buchan, Alastair M. (Author)
Format: Article (Journal)
Language:English
Published: 24 February 2013
In: Nature medicine
Year: 2013, Volume: 19, Issue: 3, Pages: 351-357
ISSN:1546-170X
DOI:10.1038/nm.3097
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.3097
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.3097
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Author Notes:Michalis Papadakis, Gina Hadley, Maria Xilouri, Lisa C. Hoyte, Simon Nagel, M. Mary McMenamin, Grigorios Tsaknakis, Suzanne M. Watt, Cynthia Wright Drakesmith, Ruoli Chen, Matthew J.A. Wood, Zonghang Zhao, Benedikt Kessler, Kostas Vekrellis & Alastair M. Buchan
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Summary:Neurons within the CA3 region of the hippocampus are relatively resistant to cell death after ischemia. Alastair M. Buchan and his colleagues demonstrate that the product of the TSC1 gene, hamartin, is upregulated in CA3 neurons in response to ischemia. Hamartin promotes survival by inhibiting mTORC1 and increasing autophagic flux in neurons.
Item Description:Gesehen am 16.12.2021
Physical Description:Online Resource
ISSN:1546-170X
DOI:10.1038/nm.3097

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