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Continuous complete remission in adult patients with acute lymphocytic leukaemia at a median observation of 12 years after autologous bone marrow transplantation

We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and m...

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Main Authors: Abdallah Khalafallah, Alhossain (Author) , Egerer, Gerlinde (Author) , Goldschmidt, Hartmut (Author) , Wannenmacher, Michael (Author) , Körbling, Martin (Author) , Ho, Anthony Dick (Author)
Format: Article (Journal)
Language:English
Published: 20 December 2001
In: British journal of haematology
Year: 2001, Volume: 112, Issue: 4, Pages: 1012-1015
ISSN:1365-2141
DOI:10.1046/j.1365-2141.2001.02634.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.2001.02634.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.2001.02634.x
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Author Notes:Alhossain Abdallah, Gerlinde Egerer, Hartmut Goldschmidt, Michael Wannenmacher, Martin Körbling, Anthony D. Ho
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Summary:We report our long-term experience with autologous bone marrow transplantation (ABMT) for 32 adult patients with acute lymphocytic leukaemia (ALL) in second or later remission (CR), or in first CR but with high-risk. Bone marrow was purged with mafosfamide (n = 25) or with immunomagnetic beads and monoclonal antibodies (n = 7). Retrospective analysis showed that 12 out of 32 patients were in continuous complete remission (CCR) at a median of 143 months (range 66-181 months). A plateau was reached at 50 months and the disease-free and overall survival rates were both 37·5%. It was notable that durable CCR could be achieved for patients in second (three out of nine) or third (one out of six) CR. ABMT could produce durable CCR and the long-term outcome compared favourably with those reported for allogeneic transplantation.
Item Description:Gesehen am 21.12.2021
Physical Description:Online Resource
ISSN:1365-2141
DOI:10.1046/j.1365-2141.2001.02634.x

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