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A summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of t...

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Main Authors: Pfister, Stefan (Author) , Reyes-Múgica, Miguel (Author) , Chan, John K. C. (Author) , Hasle, Henrik (Author) , Lazar, Alexander J. (Author) , Rossi, Sabrina (Author) , Ferrari, Andrea (Author) , Jarzembowski, Jason A. (Author) , Pritchard-Jones, Kathy (Author) , Hill, D. Ashley (Author) , Jacques, Thomas S. (Author) , Wesseling, Pieter (Author) , Terrada, Dolores H. López (Author) , Deimling, Andreas von (Author) , Kratz, Christian Peter (Author) , Cree, Ian A. (Author) , Alaggio, Rita (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Cancer discovery
Year: 2022, Volume: 12, Issue: 2, Pages: 331-355
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-21-1094
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/2159-8290.CD-21-1094
Verlag, lizenzpflichtig, Volltext: https://cancerdiscovery.aacrjournals.org/content/early/2021/12/07/2159-8290.CD-21-1094
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Author Notes:Stefan M. Pfister, Miguel Reyes-Múgica, John K. C. Chan, Henrik Hasle, Alexander J. Lazar, Sabrina Rossi, Andrea Ferrari, Jason A. Jarzembowski, Kathy Pritchard-Jones, D. Ashley Hill, Thomas S. Jacques, Pieter Wesseling, Dolores H. López Terrada, Andreas von Deimling, Christian P. Kratz, Ian A. Cree, and Rita Alaggio
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Summary:Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate. - Significance: In this review, we briefly summarize the main features and updates of each chapter of the inaugural WHO Classification of Pediatric Tumors, including its rapid transition from a mostly microscopic into a molecularly driven classification systematically taking recent discoveries in pediatric tumor genomics into account.
Item Description:Published first December 17, 2021
Gesehen am 24.02.2022
Physical Description:Online Resource
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-21-1094

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