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Optimization of sepsis therapy based on patient-specific digital precision diagnostics using next generation sequencing (DigiSep-Trial): study protocol for a randomized, controlled, interventional, open-label, multicenter trial

Sepsis is triggered by an infection and represents one of the greatest challenges of modern intensive care medicine. With regard to a targeted antimicrobial treatment strategy, the earliest possible pathogen detection is of crucial importance. Until now, culture-based detection methods represent the...

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Main Authors: Brenner, Thorsten (Author) , Skarabis, Annabell (Author) , Stevens, Philip (Author) , Axnick, Jennifer (Author) , Haug, Peter (Author) , Grumaz, Silke (Author) , Bruckner, Thomas (Author) , Luntz, Steffen P. (Author) , Witzke, Oliver (Author) , Pletz, Mathias W. (Author) , Ruprecht, Thomas M. (Author) , Marschall, Ursula (Author) , Altin, Sibel (Author) , Greiner, Wolfgang (Author) , Berger, Marc Moritz (Author)
Format: Article (Journal)
Language:English
Published: 18 October 2021
In: Trials
Year: 2021, Volume: 22, Pages: 1-12
ISSN:1468-6694
DOI:10.1186/s13063-021-05667-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13063-021-05667-x
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Author Notes:Thorsten Brenner, Annabell Skarabis, Philip Stevens, Jennifer Axnick, Peter Haug, Silke Grumaz, Thomas Bruckner, Steffen Luntz, Oliver Witzke, Mathias W. Pletz, Thomas M. Ruprecht, Ursula Marschall, Sibel Altin, Wolfgang Greiner, and Marc Moritz Berger for the TIFOnet Critical Care Trials Group
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Summary:Sepsis is triggered by an infection and represents one of the greatest challenges of modern intensive care medicine. With regard to a targeted antimicrobial treatment strategy, the earliest possible pathogen detection is of crucial importance. Until now, culture-based detection methods represent the diagnostic gold standard, although they are characterized by numerous limitations. Culture-independent molecular diagnostic procedures represent a promising alternative. In particular, the plasmatic detection of circulating, cell-free DNA by next-generation sequencing (NGS) has shown to be suitable for identifying disease-causing pathogens in patients with bloodstream infections.
Item Description:Gesehen am 30.12.2021
Physical Description:Online Resource
ISSN:1468-6694
DOI:10.1186/s13063-021-05667-x

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