Pd/C-Cu mediated direct and one-pot synthesis of γ-ylidene butenolides
10% Pd/C in combination with CuI, PPh3, and Et3N has been identified as an effective catalyst system for the coupling of (Z)-3-iodoacrylic acid with terminal alkynes in 1,4-dioxane leading to the one-pot synthesis of γ-ylidene butenolides. The methodology showed remarkable regio- and stereoselectivi...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 February 2013
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| In: |
Tetrahedron letters
Year: 2013, Volume: 54, Issue: 17, Pages: 2151-2155 |
| ISSN: | 1873-3581 |
| DOI: | 10.1016/j.tetlet.2013.02.040 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tetlet.2013.02.040 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S004040391300275X 
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| Author Notes: | D. Rambabu, S. Bhavani, Kumara Swamy Nalivela, Soumita Mukherjee, M.V. Basaveswara Rao, Manojit Pal |
| Summary: | 10% Pd/C in combination with CuI, PPh3, and Et3N has been identified as an effective catalyst system for the coupling of (Z)-3-iodoacrylic acid with terminal alkynes in 1,4-dioxane leading to the one-pot synthesis of γ-ylidene butenolides. The methodology showed remarkable regio- and stereoselectivity as only the five-membered lactone ring products were formed with an exocyclic double bond possessing Z-geometry. |
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| Item Description: | Gesehen am 07.01.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3581 |
| DOI: | 10.1016/j.tetlet.2013.02.040 |