Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in the...

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Main Authors: Renner, Marcus (Author) , Wolf, Thomas (Author) , Meyer, Hannah V. (Author) , Hartmann, Wolfgang (Author) , Penzel, Roland (Author) , Ulrich, Alexis (Author) , Lehner, Burkhard (Author) , Hovestadt, Volker (Author) , Czwan, Esteban (Author) , Egerer, Gerlinde (Author) , Schmitt, Thomas (Author) , Alldinger, Ingo (Author) , Renker, Eva Kristin (Author) , Ehemann, Volker (Author) , Eils, Roland (Author) , Wardelmann, Eva (Author) , Büttner, Reinhard (Author) , Lichter, Peter (Author) , Brors, Benedikt (Author) , Schirmacher, Peter (Author) , Mechtersheimer, Gunhild (Author)
Format: Article (Journal)
Language:English
Published: 17 December 2013
In: Genome biology
Year: 2013, Volume: 14, Issue: 12, Pages: 1-26
ISSN:1474-760X
DOI:10.1186/gb-2013-14-12-r137
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/gb-2013-14-12-r137
Verlag, lizenzpflichtig, Volltext: https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-12-r137
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Author Notes:Marcus Renner, Thomas Wolf, Hannah Meyer, Wolfgang Hartmann, Roland Penzel, Alexis Ulrich, Burkhard Lehner, Volker Hovestadt, Esteban Czwan, Gerlinde Egerer, Thomas Schmitt, Ingo Alldinger, Eva Kristin Renker, Volker Ehemann, Roland Eils, Eva Wardelmann, Reinhard Büttner, Peter Lichter, Benedikt Brors, Peter Schirmacher and Gunhild Mechtersheimer
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Summary:High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in these tumors is not well understood and, consequently, the usefulness of methylation-based classification is unclear.
Item Description:Gesehen am 07.01.2022
Physical Description:Online Resource
ISSN:1474-760X
DOI:10.1186/gb-2013-14-12-r137