Diagnostic tests for the detection of human papillomavirus-associated cervical lesions
Current diagnostic approaches for primary cervical cancer screening, work-up of equivocal or positive screening results or follow- - up after treatment of precancerous lesions primarily rely on the morphologic interpretation of squamous epithelial cells (Pap cytology), - in some setting accompanied...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
Current pharmaceutical design
Year: 2013, Volume: 19, Issue: 8, Pages: 1358-1370 |
| ISSN: | 1873-4286 |
| DOI: | 10.2174/1381612811319080002 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2174/1381612811319080002 Verlag, lizenzpflichtig, Volltext: https://www.eurekaselect.com/article/48326 
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| Author Notes: | Miriam Reuschenbach and Magnus von Knebel Doeberitz |
| Summary: | Current diagnostic approaches for primary cervical cancer screening, work-up of equivocal or positive screening results or follow- - up after treatment of precancerous lesions primarily rely on the morphologic interpretation of squamous epithelial cells (Pap cytology), - in some setting accompanied by the detection of human papillomavirus DNA and have largely contributed to remarkable reduction - of disease incidence in countries with implemented screening programs. However, these approaches are limited by a poor sensitivity and - reproducibility of Pap cytology and low specificity for high grade cervical intraepithelial neoplasia of HPV DNA detection assays. Early - detection might be improved by complementing or even replacing these tests by markers which are more directly related to molecular - events triggering HPV-induced carcinogenesis and thereby might deliver more accurate diagnostic performance. The delineation of molecular - changes which occur during different stages of HPV infections and the identification of changes which induce neoplastic alterations - allow for the detection of markers that specifically highlight the transforming stage of the infection where viral oncogenes are overexpressed - and therefore allow for a more specific diagnosis of lesions that require treatment. The evaluation of such markers in clinical - studies revealed that some indeed show an improved diagnostic performance compared to Pap cytology or HPV DNA tests only. |
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| Item Description: | Gesehen am 10.01.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4286 |
| DOI: | 10.2174/1381612811319080002 |