Diagnostic tests for the detection of human papillomavirus-associated cervical lesions
Current diagnostic approaches for primary cervical cancer screening, work-up of equivocal or positive screening results or follow- - up after treatment of precancerous lesions primarily rely on the morphologic interpretation of squamous epithelial cells (Pap cytology), - in some setting accompanied...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
|
| In: |
Current pharmaceutical design
Year: 2013, Volume: 19, Issue: 8, Pages: 1358-1370 |
| ISSN: | 1873-4286 |
| DOI: | 10.2174/1381612811319080002 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2174/1381612811319080002 Verlag, lizenzpflichtig, Volltext: https://www.eurekaselect.com/article/48326 
|
| Author Notes: | Miriam Reuschenbach and Magnus von Knebel Doeberitz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1785254790 | ||
| 003 | DE-627 | ||
| 005 | 20230426205603.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220110s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1381612811319080002 |2 doi | |
| 035 | |a (DE-627)1785254790 | ||
| 035 | |a (DE-599)KXP1785254790 | ||
| 035 | |a (OCoLC)1341436883 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Reuschenbach, Miriam |d 1980- |e VerfasserIn |0 (DE-588)13879734X |0 (DE-627)703109723 |0 (DE-576)309094054 |4 aut | |
| 245 | 1 | 0 | |a Diagnostic tests for the detection of human papillomavirus-associated cervical lesions |c Miriam Reuschenbach and Magnus von Knebel Doeberitz |
| 264 | 1 | |c 2013 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.01.2022 | ||
| 520 | |a Current diagnostic approaches for primary cervical cancer screening, work-up of equivocal or positive screening results or follow- - up after treatment of precancerous lesions primarily rely on the morphologic interpretation of squamous epithelial cells (Pap cytology), - in some setting accompanied by the detection of human papillomavirus DNA and have largely contributed to remarkable reduction - of disease incidence in countries with implemented screening programs. However, these approaches are limited by a poor sensitivity and - reproducibility of Pap cytology and low specificity for high grade cervical intraepithelial neoplasia of HPV DNA detection assays. Early - detection might be improved by complementing or even replacing these tests by markers which are more directly related to molecular - events triggering HPV-induced carcinogenesis and thereby might deliver more accurate diagnostic performance. The delineation of molecular - changes which occur during different stages of HPV infections and the identification of changes which induce neoplastic alterations - allow for the detection of markers that specifically highlight the transforming stage of the infection where viral oncogenes are overexpressed - and therefore allow for a more specific diagnosis of lesions that require treatment. The evaluation of such markers in clinical - studies revealed that some indeed show an improved diagnostic performance compared to Pap cytology or HPV DNA tests only. | ||
| 650 | 4 | |a Alphapapillomavirus | |
| 650 | 4 | |a Chromosomal Instability | |
| 650 | 4 | |a DNA Methylation | |
| 650 | 4 | |a DNA, Viral | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Reproducibility of Results | |
| 650 | 4 | |a S Phase | |
| 650 | 4 | |a Uterine Cervical Neoplasms | |
| 650 | 4 | |a Vaginal Smears | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current pharmaceutical design |d Hilversum : Bentham Science Publ., 2000 |g 19(2013), 8, Seite 1358-1370 |h Online-Ressource |w (DE-627)325051666 |w (DE-600)2034245-7 |w (DE-576)273880217 |x 1873-4286 |7 nnas |a Diagnostic tests for the detection of human papillomavirus-associated cervical lesions |
| 773 | 1 | 8 | |g volume:19 |g year:2013 |g number:8 |g pages:1358-1370 |g extent:13 |a Diagnostic tests for the detection of human papillomavirus-associated cervical lesions |
| 856 | 4 | 0 | |u https://doi.org/10.2174/1381612811319080002 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.eurekaselect.com/article/48326 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220110 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |d 50000 |e 910000PK1022165291 |e 912000PK1022165291 |e 50000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 2 |y j | ||
| 998 | |g 13879734X |a Reuschenbach, Miriam |m 13879734X:Reuschenbach, Miriam |d 910000 |d 912000 |e 910000PR13879734X |e 912000PR13879734X |k 0/910000/ |k 1/910000/912000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1785254790 |e 403219551X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1785254790","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 10.01.2022"],"title":[{"title":"Diagnostic tests for the detection of human papillomavirus-associated cervical lesions","title_sort":"Diagnostic tests for the detection of human papillomavirus-associated cervical lesions"}],"person":[{"family":"Reuschenbach","given":"Miriam","display":"Reuschenbach, Miriam","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Knebel Doeberitz, Magnus von","roleDisplay":"VerfasserIn","given":"Magnus von","family":"Knebel Doeberitz"}],"relHost":[{"id":{"issn":["1873-4286"],"eki":["325051666"],"zdb":["2034245-7"]},"origin":[{"dateIssuedKey":"2000","publisher":"Bentham Science Publ.","dateIssuedDisp":"2000-","publisherPlace":"Hilversum"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Current pharmaceutical design","subtitle":"dispatches from the front line of drug design","title_sort":"Current pharmaceutical design"}],"language":["eng"],"recId":"325051666","disp":"Diagnostic tests for the detection of human papillomavirus-associated cervical lesionsCurrent pharmaceutical design","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 15.04.24"],"part":{"pages":"1358-1370","issue":"8","year":"2013","extent":"13","text":"19(2013), 8, Seite 1358-1370","volume":"19"},"pubHistory":["Nachgewiesen 6.2000 -"]}],"physDesc":[{"extent":"13 S."}],"id":{"eki":["1785254790"],"doi":["10.2174/1381612811319080002"]},"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"name":{"displayForm":["Miriam Reuschenbach and Magnus von Knebel Doeberitz"]}} | ||
| SRT | |a REUSCHENBADIAGNOSTIC2013 | ||