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Vancomycin resistance is overcome by conjugation of polycationic peptides

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Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized.

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Bibliographic Details
Main Authors: Umstätter, Florian (Author) , Domhan, Cornelius (Author) , Hertlein, Tobias (Author) , Ohlsen, Knut (Author) , Mühlberg, Eric (Author) , Kleist, Christian (Author) , Zimmermann, Stefan (Author) , Beijer, Barbro (Author) , Klika, Karel D. (Author) , Haberkorn, Uwe (Author) , Mier, Walter (Author) , Uhl, Philipp (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Angewandte Chemie. International edition
Year: 2020, Volume: 59, Issue: 23, Pages: 8823-8827
ISSN:1521-3773
DOI:10.1002/anie.202002727
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.202002727
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/anie.202002727
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Author Notes:Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, and Philipp Uhl
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Summary:Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized.
Item Description:Version of record online: April 21, 2020
Gesehen am 11.02.2022
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.202002727

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