Vancomycin resistance is overcome by conjugation of polycationic peptides
Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized.
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
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| In: |
Angewandte Chemie. International edition
Year: 2020, Jahrgang: 59, Heft: 23, Pages: 8823-8827 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.202002727 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.202002727 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/anie.202002727 |
| Verfasserangaben: | Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, and Philipp Uhl |
| Zusammenfassung: | Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized. |
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| Beschreibung: | Version of record online: April 21, 2020 Gesehen am 11.02.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.202002727 |