Fms-like tyrosine kinase 3 receptor ligand (Flt3L)-based vaccination administered with an adenoviral vector prevents tumor growth of colorectal cancer in a BALB/c mouse model
Colorectal cancer is the third most frequent cancer in industrial nations. Therapeutic strategies to treat metastatic disease and prevent recurrence are needed. Anti-tumor immunity can be induced by dendritic cells. Dendritic cells can be expanded by the fms-like tyrosine kinase 3 ligand (Flt3L) in...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 October 2013
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| In: |
Journal of cancer research and clinical oncology
Year: 2013, Volume: 139, Issue: 12, Pages: 2097-2110 |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-013-1532-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00432-013-1532-z Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007%2Fs00432-013-1532-z 
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| Author Notes: | Carina Riediger · Gerhard Wingender · Percy Knolle · Sebastian Aulmann · Wolfgang Stremmel · Jens Encke |
| Summary: | Colorectal cancer is the third most frequent cancer in industrial nations. Therapeutic strategies to treat metastatic disease and prevent recurrence are needed. Anti-tumor immunity can be induced by dendritic cells. Dendritic cells can be expanded by the fms-like tyrosine kinase 3 ligand (Flt3L) in vivo. The aim of this study was to develop an adenoviral-based immune-gene therapy of colorectal cancer with Flt3L in a BALB/c mouse model. |
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| Item Description: | Gesehen am 12.01.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-013-1532-z |