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Comparison of different lymphoma cell purging modalities: an experimental study with K422 lymphoma cells

Blood-derived autografts from patients with non-Hodgkin’s lymphoma (NHL) are frequently contaminated with clonogenic lymphoma cells. In order to obtain a more efficient lymphoma cell depletion from the transplants we compared the efficiency of different purging techniques: B-cell-directed depletion,...

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Bibliographic Details
Main Authors: Hundsdörfer, Patrick (Author) , Frühauf, Stefan (Author) , Haberkorn, M. (Author) , Höft, Raimund (Author) , Haas, Rainer (Author) , Zeller, W. Jens (Author)
Format: Article (Journal)
Language:English
Published: July 22, 1999
In: Acta haematologica
Year: 1999, Volume: 101, Issue: 4, Pages: 185-192
ISSN:1421-9662
DOI:10.1159/000040951
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1159/000040951
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/40951
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Author Notes:P. Hundsdörfer, S. Fruehauf, M. Haberkorn, R. Höft, R. Haas, W. J. Zeller
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Summary:Blood-derived autografts from patients with non-Hodgkin’s lymphoma (NHL) are frequently contaminated with clonogenic lymphoma cells. In order to obtain a more efficient lymphoma cell depletion from the transplants we compared the efficiency of different purging techniques: B-cell-directed depletion, CD34+ selection by immunomagnetic beads (IMB selection) or by immunoadsorption with a biotin-avidin column (BAC selection). Furthermore, two combination approaches were investigated: IMB selection after B-cell depletion as well as BAC selection after B-cell depletion.
Item Description:Gesehen am 12.01.2022
Physical Description:Online Resource
ISSN:1421-9662
DOI:10.1159/000040951

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