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Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma

Thymosin β4 (Tβ4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tβ4 expression was significantly...

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Main Authors: Caers, Jo (Author) , Hose, Dirk (Author) , Kuipers, Ine (Author) , Bos, Tomas Jan (Author) , Van Valckenborgh, Els (Author) , Menu, Eline (Author) , De Bruyne, Elke (Author) , Goldschmidt, Hartmut (Author) , Van Camp, Ben (Author) , Klein, Bernard (Author) , Vanderkerken, Karin (Author)
Format: Article (Journal)
Language:English
Published: [2010]
In: Haematologica, the hematology journal
Year: 2009, Volume: 95, Issue: 1, Pages: 163-167
ISSN:1592-8721
DOI:10.3324/haematol.2009.006411
Online Access:Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805724/
Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2009.006411
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Author Notes:Jo Caers, Dirk Hose, Ine Kuipers, Tomas Jan Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Ben Van Camp, Bernard Klein, Karin Vanderkerken
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Summary:Thymosin β4 (Tβ4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tβ4 expression was significantly lower in myeloma cells compared to normal plasma cells (P<0.001). The same observation can be made in the 5TMM-mouse model by qRT-PCR and ELISA. Here, Tβ4 overexpression by lentiviral transduction of 5T33MMvt-cells led to significantly decreased proliferative and migratory capacities and increased sensitivity to apoptosis-induction. Mice injected with Tβ4 over-expressing myeloma cells showed a longer survival compared to mice injected with controls (88,9 vs. 65,9 days, P<0.05). In 209 MM patients treated with high-dose therapy and autologous stem cell transplantation, expression of Tβ4 below the median was associated with a significantly shorter event free survival (37.6 vs. 26.2 months, P<0.05). In conclusion, our results indicate a possible tumor suppressive function of Tβ4.
Item Description:Published online 2009 Oct 14
Gesehen am 12.01.2022
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2009.006411

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