A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study
Background aims - Previous studies in xenograft models have shown that human peripheral blood progenitor cells (PBPC) mobilized with the CXCR4 antagonist plerixafor (AMD3100) have a higher bone marrow (BM) reconstitution potential than granulocyte-colony-stimulating factor (G-CSF)-mobilized PBPC. -...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2009]
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| In: |
Cytotherapy
Year: 2009, Jahrgang: 11, Heft: 8, Pages: 992-1001 |
| ISSN: | 1477-2566 |
| DOI: | 10.3109/14653240903121245 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/14653240903121245 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1465324909703470 
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| Verfasserangaben: | Stefan Fruehauf, Marlon Romano Veldwijk, Timon Seeger, Mario Schubert, Stephanie Laufs, Julian Topaly, Patrick Wuchter, Falk Dillmann, Volker Eckstein, Frederik Wenz, Hartmut Goldschmidt, Anthony Dick Ho and Gary Calandra |
MARC
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| 245 | 1 | 2 | |a A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone |b results of a European phase II study |c Stefan Fruehauf, Marlon Romano Veldwijk, Timon Seeger, Mario Schubert, Stephanie Laufs, Julian Topaly, Patrick Wuchter, Falk Dillmann, Volker Eckstein, Frederik Wenz, Hartmut Goldschmidt, Anthony Dick Ho and Gary Calandra |
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| 520 | |a Background aims - Previous studies in xenograft models have shown that human peripheral blood progenitor cells (PBPC) mobilized with the CXCR4 antagonist plerixafor (AMD3100) have a higher bone marrow (BM) reconstitution potential than granulocyte-colony-stimulating factor (G-CSF)-mobilized PBPC. - Methods - PBPC obtained during G-CSF-supported mobilization before and after a supplementary administration of AMD3100 from patients with multiple myeloma and non-Hodgkin's lymphoma (n=15; phase II study) were investigated for co-expression of primitive and lineage-associated markers, their proliferative activity in vitro and repopulation potential after clinical transplantation. - Results - A significant increase in primitive CD34+ CD38− cells was observed in intraindividual comparisons of all patients after administration of G-CSF+AMD3100 (peripheral blood: median 8-fold, range 2,4-fold - 39-fold) compared with G-CSF alone. Using a long-term culture-initiating cell assay, this increase was confirmed. After transplantation of G-CSF+AMD3100-mobilized PBPC, the time to leukocyte reconstitution >1×103/μL and platelet reconstitution >2×104/μL was 14 (10-19 days) and 13 days (10-15 days), respectively. A complete and stable hematologic reconstitution (platelets >1.5×105/μL) was observed in 91% of all patients within 35 days. - Conclusions - An additional application of AMD3100 to a standard G-CSF mobilization regimen leads to a significant increase in primitive PBPC with high repopulation capacity. | ||
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