Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin.

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Bibliographic Details
Main Authors:	Panwalkar, Pooja (Author) , Tamrazi, Benita (Author) , Dang, Derek (Author) , Chung, Chan (Author) , Sweha, Stefan (Author) , Natarajan, Siva Kumar (Author) , Pun, Matthew (Author) , Bayliss, Jill (Author) , Ogrodzinski, Martin P. (Author) , Pratt, Drew (Author) , Mullan, Brendan (Author) , Hawes, Debra (Author) , Yang, Fusheng (Author) , Lu, Chao (Author) , Sabari, Benjamin R. (Author) , Achreja, Abhinav (Author) , Heon, Jin (Author) , Animasahun, Olamide (Author) , Cieslik, Marcin (Author) , Dunham, Christopher (Author) , Yip, Stephen (Author) , Hukin, Juliette (Author) , Phillips, Joanna J. (Author) , Bornhorst, Miriam (Author) , Griesinger, Andrea M. (Author) , Donson, Andrew M. (Author) , Foreman, Nicholas K. (Author) , Garton, Hugh J. L. (Author) , Heth, Jason (Author) , Muraszko, Karin (Author) , Nazarian, Javad (Author) , Koschmann, Carl (Author) , Jiang, Li (Author) , Filbin, Mariella G. (Author) , Nagrath, Deepak (Author) , Kool, Marcel (Author) , Korshunov, Andrey (Author) , Pfister, Stefan (Author) , Gilbertson, Richard J. (Author) , Allis, C. David (Author) , Chinnaiyan, Arul M. (Author) , Lunt, Sophia Y. (Author) , Blüml, Stefan (Author) , Judkins, Alexander R. (Author) , Venneti, Sriram (Author)
Format:	Article (Journal)
Language:	English
Published:	6 Oct 2021
In:	Science translational medicine Year: 2021, Volume: 13, Issue: 614, Pages: 1-13
ISSN:	1946-6242
DOI:	10.1126/scitranslmed.abc0497
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/scitranslmed.abc0497 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/abs/10.1126/scitranslmed.abc0497
Author Notes:	Pooja Panwalkar, Benita Tamrazi, Derek Dang, Chan Chung, Stefan Sweha, Siva Kumar Natarajan, Matthew Pun, Jill Bayliss, Martin P. Ogrodzinski, Drew Pratt, Brendan Mullan, Debra Hawes, Fusheng Yang, Chao Lu, Benjamin R. Sabari, Abhinav Achreja, Jin Heon, Olamide Animasahun, Marcin Cieslik, Christopher Dunham, Stephen Yip, Juliette Hukin, Joanna J. Phillips, Miriam Bornhorst, Andrea M. Griesinger, Andrew M. Donson, Nicholas K. Foreman, Hugh J. L. Garton, Jason Heth, Karin Muraszko, Javad Nazarian, Carl Koschmann, Li Jiang, Mariella G. Filbin, Deepak Nagrath, Marcel Kool, Andrey Korshunov, Stefan M. Pfister, Richard J. Gilbertson, C. David Allis, Arul M. Chinnaiyan, Sophia Y. Lunt, Stefan Blüml, Alexander R. Judkins, Sriram Venneti

Description
Summary:	Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin.
Item Description:	Gesehen am 17.01.2022
Physical Description:	Online Resource
ISSN:	1946-6242
DOI:	10.1126/scitranslmed.abc0497