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Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

Objectives - To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. - Methods - Individual patient data (IPD) and aggregated meta-anal...

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Main Authors: Bernard, Paquito (Author) , Savard, J. (Author) , Steindorf, Karen (Author) , Sweegers, M. G. (Author) , Courneya, K. S. (Author) , Newton, R. U. (Author) , Aaronson, N. K. (Author) , Jacobsen, P. B. (Author) , May, A. M. (Author) , Galvao, D. A. (Author) , Chinapaw, M. J. (Author) , Stuiver, M. M. (Author) , Griffith, K. A. (Author) , Mesters, I. (Author) , Knoop, H. (Author) , Goedendorp, M. M. (Author) , Bohus, Martin (Author) , Thorsen, L. (Author) , Schmidt, Martina (Author) , Ulrich, C. M. (Author) , Sonke, G. S. (Author) , van Harten, W. (Author) , Winters-Stone, K. M. (Author) , Velthuis, M. J. (Author) , Taaffe, D. R. (Author) , van Mechelen, W. (Author) , Kersten, M. J. (Author) , Nollet, F. (Author) , Wenzel, J. (Author) , Wiskemann, Joachim (Author) , Verdonck-de Leeuw, I. M. (Author) , Brug, J. (Author) , Buffart, L. M. (Author)
Format: Article (Journal)
Language:English
Published: 23 June 2019
In: Journal of psychosomatic research
Year: 2019, Volume: 124, Pages: 1-9
ISSN:1879-1360
DOI:10.1016/j.jpsychores.2019.109746
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jpsychores.2019.109746
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S002239991930193X
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Author Notes:P. Bernard, J. Savard, K. Steindorf, M. G. Sweegers, K. S. Courneya, R. U. Newton, N. K. Aaronson, P. B. Jacobsen, A. M. May, D. A. Galvao, M. J. Chinapaw, M. M. Stuiver, K. A. Griffith, I. Mesters, H. Knoop, M. M. Goedendorp, M. Bohus, L. Thorsen, M. E. Schmidt, C. M. Ulrich, G. S. Sonke, W. van Harten, K. M. Winters-Stone, M. J. Velthuis, D. R. Taaffe, W. van Mechelen, M. J. Kersten, F. Nollet, J. Wenzel, J. Wiskemann, I. M. Verdonck-de Leeuw, J. Brug, L. M. Buffart
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Summary:Objectives - To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. - Methods - Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age=54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. - Results - For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g=−0.09, 95% CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. - Conclusions - This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.
Item Description:Gesehen am 19.01.2021
Physical Description:Online Resource
ISSN:1879-1360
DOI:10.1016/j.jpsychores.2019.109746

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